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Peptide record

TPDB29503

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB29503
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCCGVKLEMCHPCLCDNSCKKSGK
Physicochemical Analysis
C102H173N31O34S7
ARQIFTWY
C
2602.10
7.64
5
3
4
+1
7.83
-0.337
44.58
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
375
14.41
9
Residue Composition
number
0
A
0
R
1
N
2
D
6
C
1
E
0
Q
2
G
1
H
0
I
2
L
4
K
1
M
0
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 2 C: 6 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 2 K: 4 M: 1 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C102H173N31O34S7
2602.10
7.64
+1
7.83
-0.337
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin with ion channel inhibitor activity (Probable). In vivo, elicits dose-dependently excitatory activity upon injection into fish. Its action is slowly reversible (By similarity). {ECO:0000250|UniProtKB:P0C2C5, ECO:0000305}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus purpurascens (Purple cone)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin with ion channel inhibitor activity (Probable). In vivo, elicits dose-dependently excitatory activity upon injection into fish.
Conotoxin PIVF (Kappa-conotoxin-like PIVF) (KappaA-PIVF)
cone snail
Conotoxin A superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17118419}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Conotoxin PIVF (Kappa-conotoxin-like PIVF) (KappaA-PIVF)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17118419}.
cone snail