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Peptide record

TPDB29326

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB29326
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CSRSDGWCGKTEDCCCPMKCIKAWYKQNGNCQNTISAIWKNC
Physicochemical Analysis
C198H307N59O61S9
HLFV
C
4778.51
8.10
6
3
10
+3
4.32
-0.645
32.62
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
18490
386.94
20
Residue Composition
number
2
A
1
R
4
N
2
D
8
C
1
E
2
Q
3
G
0
H
3
I
0
L
5
K
1
M
0
F
1
P
3
S
2
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 4 D: 2 C: 8 E: 1 Q: 2 G: 3 H: 0 I: 3 L: 0 K: 5 M: 1 F: 0 P: 1 S: 3 T: 2 W: 3 Y: 1 V: 0
Chemical Descriptors
42
C198H307N59O61S9
4778.51
8.10
+3
4.32
-0.645
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lethal neurotoxin. Slows the inactivation of tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3 of the channel, resulting in repetitive firing in autonomic and motor nerve fibers. {ECO:0000269|PubMed:10745084}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Lethal neurotoxin. Slows the inactivation of tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3 of the channel, resulting in repetitive firing in autonomic and motor nerve fibers..
Delta-hexatoxin-Hv1b (Delta-HXTX-Hv1b) (Delta-atracotoxin-Hv1b) (Delta-ACTX-Hv1b)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10745084}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Hv1b (Delta-HXTX-Hv1b) (Delta-atracotoxin-Hv1b) (Delta-ACTX-Hv1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10745084}.
spider