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Peptide record

TPDB29229

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB29229
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CQAYGESCSAVVRCCDPNAVCCQYPEDAVCVTRGYCRPPATVLT
Physicochemical Analysis
C194H306N56O64S8
HIKMFW
C
4703.38
4.56
3
4
15
-1
7.28
0.118
59.77
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
4970
105.67
19
Residue Composition
number
5
A
3
R
1
N
2
D
8
C
2
E
2
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
4
P
2
S
3
T
0
W
3
Y
6
V
Amino Acid Distribution
A: 5 R: 3 N: 1 D: 2 C: 8 E: 2 Q: 2 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 4 S: 2 T: 3 W: 0 Y: 3 V: 6
Chemical Descriptors
44
C194H306N56O64S8
4703.38
4.56
-1
7.28
0.118
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Elicits hypersensibility when injected intracranially in mice. May act via potassium channel currents. {ECO:0000269|PubMed:15581690, ECO:0000269|Ref.2}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus regius (Crown cone)
Neurotoxin
Neurotoxin. Elicits hypersensibility when injected intracranially in mice.
Conotoxin Rg11a
cone snail
Conotoxin I1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:15581690}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin I1 superfamily
Conotoxin Rg11a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:15581690}.
cone snail