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Peptide record

TPDB29210

Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB29210
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CLSPGSSCSPTSYNCCRSCNPYSRKC
Physicochemical Analysis
C110H175N35O39S6
ADEQHIMFWV
S
2804.17
8.31
3
0
3
+3
1.98
-0.585
15.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3355
119.64
18
Residue Composition
number
0
A
2
R
2
N
0
D
6
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
3
P
7
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 6 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 3 S: 7 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
26
C110H175N35O39S6
2804.17
8.31
+3
1.98
-0.585
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
Omega-conotoxin TVIA (SNX-185)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin TVIA (SNX-185)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail