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Peptide record

TPDB29201

Apamin Apomin Apoo Blood-Brain Barrier Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB29201
Apamin Apomin Apoo
Blood-Brain Barrier Toxicity
Toxicity and safety peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 18-aa standard natural multi-activity (Blood-Brain Barrier and Toxicity) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
CNCKAPETALCARRCQQH
Physicochemical Analysis
C79H134N30O25S4
DGIMFSWYV
C
2032.36
8.31
4
1
4
+2
5.73
-0.733
38.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
250
12.30
8
Residue Composition
number
3
A
2
R
1
N
0
D
4
C
1
E
2
Q
0
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 4 E: 1 Q: 2 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C79H134N30O25S4
2032.36
8.31
+2
5.73
-0.733
Linear Cyclic
Similarity
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
The difference in peptide concentration between donor and acceptor cell was below 1%, indicate cells
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.7+/- 0.1 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 3 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.6+/- 0.2 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 4 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

100 microliter of peptide
BBB-RTU cell kit assay PAMPA method
2.3+/- 0.7 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 5 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.8+/- 0.1 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 6 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.7+/- 0.2 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 7 Activity

Activity

Blood-Brain Barrier

Target

Caco-2 cell line

Assay & Model

100 microliter of peptide
BBB-RTU cell kit assay PAMPA method
2.5+/- 0.8 apparent permeability
Origin/Source
CNS

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Evidence 8 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb