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Peptide record

TPDB29199

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB29199
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CMGYDIHCTDRLPCCFGLECVKTSGYWWYKKTYCRRKS
Physicochemical Analysis
C203H303N55O54S7
ANQ
C
4602.40
8.56
8
3
12
+4
1.37
-0.534
38.42
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
17335
376.65
15
Residue Composition
number
0
A
3
R
0
N
2
D
6
C
1
E
0
Q
3
G
1
H
1
I
2
L
4
K
1
M
1
F
1
P
2
S
3
T
2
W
4
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 1 L: 2 K: 4 M: 1 F: 1 P: 1 S: 2 T: 3 W: 2 Y: 4 V: 1
Chemical Descriptors
38
C203H303N55O54S7
4602.40
8.56
+4
1.37
-0.534
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin. Shows competition for site 3 of insect voltage-gated sodium channels (Nav). {ECO:0000269|PubMed:12860384}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin. Shows competition for site 3 of insect voltage-gated sodium channels (Nav)..
Mu-hexatoxin-Mg1b (Mu-HXTX-Mg1b) (Neurotoxin magi-1)
spider
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12860384, ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Mu-hexatoxin-Mg1b (Mu-HXTX-Mg1b) (Neurotoxin magi-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12860384, ECO:0000305}.
spider