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Peptide record

TPDB29179

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB29179
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKSPGTPCSRGMRDCCTSCLLYSNKCRRY
Physicochemical Analysis
C131H218N44O41S7
AEQHIFWV
C
3289.86
8.89
6
1
5
+5
3.92
-0.672
26.90
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3355
101.98
15
Residue Composition
number
0
A
4
R
1
N
1
D
6
C
0
E
0
Q
2
G
0
H
0
I
2
L
2
K
1
M
0
F
2
P
4
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 2 M: 1 F: 0 P: 2 S: 4 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
29
C131H218N44O41S7
3289.86
8.89
+5
3.92
-0.672
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
Omega-conotoxins GVIIA/GVIIB (SNX-178) (Shaker peptides GVIIA/GVIIB)
cone snail
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:4071055}.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-conotoxins GVIIA/GVIIB (SNX-178) (Shaker peptides GVIIA/GVIIB)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:4071055}.
cone snail