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Peptide record

TPDB29134

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB29134
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CLQFGSTCFLGDDDICCSGECFYSGGTFGICS
Physicochemical Analysis
C141H203N33O49S6
ARNHKMPWV
CG
3336.71
2.78
0
4
9
-4
-1.49
0.531
48.75
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
55.89
14
Residue Composition
number
0
A
0
R
0
N
3
D
6
C
1
E
1
Q
6
G
0
H
2
I
2
L
0
K
0
M
4
F
0
P
4
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 3 C: 6 E: 1 Q: 1 G: 6 H: 0 I: 2 L: 2 K: 0 M: 0 F: 4 P: 0 S: 4 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
32
C141H203N33O49S6
3336.71
2.78
-4
-1.49
0.531
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Elicits hyperactivity when injected intracranially into mice and produces paralysis when injected into the pedal muscle of freshwater snails, Pomacea paludosa, but it has no apparent effect after intramuscular injection into the limpet Patella opea or the freshwater fish Lebistes reticulatus.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus spurius (Alphabet cone)
Neurotoxin
Elicits hyperactivity when injected intracranially into mice and produces paralysis when injected into the pedal muscle of freshwater snails, Pomacea paludosa, but it has no apparent effect after intramuscular injection into the limpet Patella opea or the freshwater fish Lebistes reticulatus.
Conotoxin sr7a
cone snail
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17166626}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin sr7a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17166626}.
cone snail