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Peptide record

TPDB29126

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB29126
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKPPGSPCRVSSYNCCSSCKSYNKKCG
Physicochemical Analysis
C116H188N36O38S6
ADEQHILMFTW
CS
2887.35
8.87
5
0
3
+5
4.51
-0.774
10.74
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3355
116.20
16
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
0
E
0
Q
2
G
0
H
0
I
0
L
4
K
0
M
0
F
3
P
6
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 3 S: 6 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
27
C116H188N36O38S6
2887.35
8.87
+5
4.51
-0.774
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
Omega-conotoxin RVIA
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin RVIA
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail