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Peptide record

TPDB29107

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB29107
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CLGENVPCDKDRPNCCSKYECLEPTGYGRCYASYYSYKKKTL
Physicochemical Analysis
C209H319N55O66S6
QHIMFW
CY
4850.52
8.00
7
5
11
+2
9.12
-0.910
37.14
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
9315
192.04
19
Residue Composition
number
1
A
2
R
2
N
2
D
6
C
3
E
0
Q
3
G
0
H
0
I
3
L
5
K
0
M
0
F
3
P
3
S
2
T
0
W
6
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 2 C: 6 E: 3 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 5 M: 0 F: 0 P: 3 S: 3 T: 2 W: 0 Y: 6 V: 1
Chemical Descriptors
42
C209H319N55O66S6
4850.52
8.00
+2
9.12
-0.910
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells. {ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Aphonopelma sp. (American tarantula)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells..
Omega-theraphotoxin-Asp3a (Omega-TRTX-Asp3a) (Peptide 7-13.2)
spider
Neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily
Omega-theraphotoxin-Asp3a (Omega-TRTX-Asp3a) (Peptide 7-13.2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider