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Peptide record

TPDB29063

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB29063
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CKGQSCSSCSTKEFCLSKGSRLMYDCCTGSCCGVKTAGVT
Physicochemical Analysis
C163H272N48O58S9
NHIPW
C
4120.78
8.10
5
2
8
+3
4.75
0.005
36.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1990
48.29
21
Residue Composition
number
1
A
1
R
0
N
1
D
8
C
1
E
1
Q
5
G
0
H
0
I
2
L
4
K
1
M
1
F
0
P
7
S
4
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 8 E: 1 Q: 1 G: 5 H: 0 I: 0 L: 2 K: 4 M: 1 F: 1 P: 0 S: 7 T: 4 W: 0 Y: 1 V: 2
Chemical Descriptors
40
C163H272N48O58S9
4120.78
8.10
+3
4.75
0.005
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin inhibits rat Cav2.2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2.8 uM), whose effect is partially reversed after washing. In vivo, when injected into mice, it shows both an analgesic effect in acute thermal pain at 30 and 45 minutes post-injection and an anti-nociceptive effect in a formalin chronic pain test. {ECO:0000269|PubMed:23567319}.

Target

voltage-gated calcium channel (Cav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus regularis (Regular cone)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin inhibits rat Cav2.2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2.8 uM), whose effect is partially reversed after washing.
Omega-conotoxin RsXXVIA (RsXXIVA)
cone snail
Evidence at protein level
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23567319}.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-conotoxin RsXXVIA (RsXXIVA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23567319}.
cone snail