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Peptide record

TPDB29058

Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB29058
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKGKGQSCSKLMYDCCTGSCSRRGKC
Physicochemical Analysis
C107H185N37O36S7
ANEHIFPWV
C
2790.29
8.89
6
1
3
+5
4.92
-0.681
15.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
66.84
13
Residue Composition
number
0
A
2
R
0
N
1
D
6
C
0
E
1
Q
4
G
0
H
0
I
1
L
4
K
1
M
0
F
0
P
4
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 1 K: 4 M: 1 F: 0 P: 0 S: 4 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
26
C107H185N37O36S7
2790.29
8.89
+5
4.92
-0.681
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels. {ECO:0000269|PubMed:10938268}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus catus (Cat cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels..
Omega-conotoxin CVIC
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin CVIC
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail