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Peptide record

TPDB29042

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB29042
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKGKGASCRKTMYDCCRGSCRSGRC
Physicochemical Analysis
C102H178N40O33S7
NEQHILFPWV
C
2717.20
9.29
7
1
3
+6
5.23
-0.820
4.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
68.64
11
Residue Composition
number
1
A
4
R
0
N
1
D
6
C
0
E
0
Q
4
G
0
H
0
I
0
L
3
K
1
M
0
F
0
P
3
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 3 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C102H178N40O33S7
2717.20
9.29
+6
5.23
-0.820
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels (PubMed:10938268). It shows high activities on Cav2.1/CACNA1A (IC(50)=11 nM) and Cav2.2/CACNA1B (IC(50)=7.7 nM) (PubMed:10938268). In addition, it shows a higher potency when Cav2.2/CACNA1B is only expressed with the ancillary subunit CACNB3 (IC(50)=1.6 nM) than on Cav2.2/CACNA1B expressed with the ancillary subunits CACNA2D1 and CACNB3 (IC(50)=12 nM) (PubMed:19892914). Both the Cav2.2/CACNA1B block by this toxin and the recovery are voltage-independent (PubMed:19892914). It is noteworthy that ancillary subunits beta do not modulate recovery from this toxin block, since Cav2.2/CACNA1B expressed with either the ancillary subunit CACNB2a (isoform 2a) or with CACNB3 exhibits moderate recovery (PubMed:19892914). {ECO:0000269|PubMed:10938268, ECO:0000269|PubMed:19892914}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus catus (Cat cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels (PubMed:10938268).
Omega-conotoxin CVIB
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10938268}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin CVIB
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10938268}.
cone snail