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Peptide record

TPDB29037

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB29037
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKGKGASCHRTSYDCCTGSCNRGKC
Physicochemical Analysis
C99H165N37O35S6
EQILMFPWV
C
2625.99
8.59
6
1
2
+4
5.36
-0.832
4.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
71.02
13
Residue Composition
number
1
A
2
R
1
N
1
D
6
C
0
E
0
Q
4
G
1
H
0
I
0
L
3
K
0
M
0
F
0
P
3
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 3 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C99H165N37O35S6
2625.99
8.59
+4
5.36
-0.832
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). {ECO:0000269|PubMed:2441741}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav)..
Omega-conotoxin MVIIB (SNX-159)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:2441741}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin MVIIB (SNX-159)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:2441741}.
cone snail