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Peptide record

TPDB29034

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB29034
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CKGKGAPCTRLMYDCCHGSCSSSKGRCG
Physicochemical Analysis
C112H187N39O37S7
NEQIFWV
C
2896.38
8.59
6
1
4
+4
4.60
-0.489
17.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
64.39
12
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
0
E
0
Q
5
G
1
H
0
I
1
L
3
K
1
M
0
F
1
P
4
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 5 H: 1 I: 0 L: 1 K: 3 M: 1 F: 0 P: 1 S: 4 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C112H187N39O37S7
2896.38
8.59
+4
4.60
-0.489
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with high potency. Unexpectedly, it does not show any blocking activity at amphibian neuromuscular junction. In vivo, when intracerebroventricularly injected into mice causes shaking activity, and, at higher doses, causes mild tremors. When injected intramuscularly into fish, it causes paralysis, and, at higher doses, causes death. {ECO:0000269|PubMed:11724570}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with high potency.
Omega-conotoxin-like CnVIIH [Cleaved into: Omega-conotoxin CnVIIA]
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Oxidation Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11724570}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Oxidation Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin-like CnVIIH [Cleaved into: Omega-conotoxin CnVIIA]
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11724570}.
cone snail