Back to search

Peptide record

TPDB28958

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28958
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CGTNRAWCRNAKDHCCCGYSCVKPIWASKPEDDGYCWKKFGGC
Physicochemical Analysis
C207H305N61O59S8
QLM
C
4848.55
8.09
8
4
11
+3
4.20
-0.665
22.79
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
19980
412.08
15
Residue Composition
number
3
A
2
R
2
N
3
D
8
C
1
E
0
Q
5
G
1
H
1
I
0
L
5
K
0
M
1
F
2
P
2
S
1
T
3
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 3 C: 8 E: 1 Q: 0 G: 5 H: 1 I: 1 L: 0 K: 5 M: 0 F: 1 P: 2 S: 2 T: 1 W: 3 Y: 2 V: 1
Chemical Descriptors
43
C207H305N61O59S8
4848.55
8.09
+3
4.20
-0.665
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This toxin blocks the neuromuscular transmission, and also acts on muscle. It exerts an effect of first exciting and then inhibiting the contraction of muscle. This toxin is active only against mammals. {ECO:0000269|PubMed:12727269}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele raveni (Funnel-web spider)
Neurotoxin
This toxin blocks the neuromuscular transmission, and also acts on muscle. It exerts an effect of first exciting and then inhibiting the contraction of muscle.
U5-hexatoxin-Mr1a (U5-HXTX-Mr1a) (Raventoxin I) (Raventoxin-1)
spider
Neurotoxin 35 family
Evidence at protein level
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 35 family
U5-hexatoxin-Mr1a (U5-HXTX-Mr1a) (Raventoxin I) (Raventoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider