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Peptide record

TPDB28925

Melittin Cell-penetrating Peptides Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB28925
Melittin
Cell-penetrating Peptides Toxicity
Toxicity and safety peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 26-aa standard natural multi-activity (Cell-penetrating Peptides and Toxicity) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
CIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
C132H230N38O32S1
NDEHMFY
L
2893.57
11.56
5
0
12
+5
1.17
0.385
135.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
190.08
6
Residue Composition
number
2
A
2
R
0
N
0
D
1
C
0
E
2
Q
2
G
0
H
3
I
4
L
3
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 2 H: 0 I: 3 L: 4 K: 3 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C132H230N38O32S1
2893.57
11.56
+5
1.17
0.385
Free
L
Amphipathic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HT-29-luc cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
PNA
Endocytosis
In vitro
CCHHHHHHHHHTSHHHHHHHHTTCCC
Additional Detail Fields 1 fields
CCHHHHHHHHHTSHHHHHHHHTTCCC