Back to search

Peptide record

TPDB28876

Neurotoxin Toxicity standard
50 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28876
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 50-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CGDINAPCQSDCDCCGYSVTCDCYWSKDCKCRESNFVIGMALRKAFCKNK
Physicochemical Analysis
C230H358N66O74S11
H
C
5584.43
7.37
7
6
14
+1
7.55
-0.292
41.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
9105
163.04
21
Residue Composition
number
3
A
2
R
3
N
5
D
10
C
1
E
1
Q
3
G
0
H
2
I
1
L
5
K
1
M
2
F
1
P
4
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 5 C: 10 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 1 K: 5 M: 1 F: 2 P: 1 S: 4 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
50
C230H358N66O74S11
5584.43
7.37
+1
7.55
-0.292
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects. {ECO:0000250|UniProtKB:P59367}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects..
U2-ctenitoxin-Pk1a (U2-CNTX-Pk1a) (Neurotoxin PKTx20C2)
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16278100}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
U2-ctenitoxin-Pk1a (U2-CNTX-Pk1a) (Neurotoxin PKTx20C2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16278100}.
spider