Back to search

Peptide record

TPDB28830

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28830
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CDAPTHYCTNYWECCSGYCEHSHCW
Physicochemical Analysis
C127H164N34O40S6
RQILKMFV
C
2999.26
5.07
3
3
6
-3
1.44
-0.700
4.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
15845
528.30
14
Residue Composition
number
1
A
0
R
1
N
1
D
6
C
2
E
0
Q
1
G
3
H
0
I
0
L
0
K
0
M
0
F
1
P
2
S
2
T
2
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 6 E: 2 Q: 0 G: 1 H: 3 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 2 W: 2 Y: 3 V: 0
Chemical Descriptors
25
C127H164N34O40S6
2999.26
5.07
-3
1.44
-0.700
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Micromolar concentrations of PiVIIA increase the magnitude of the macroscopic calcium current in DRG neurons from rat. An increase, even modest of the calcium current, may have a significant impact in the excitability and electrical activity of neurons, and may set up PiVIIA as a member of the pharmacological family of the gamma-conotoxins. {ECO:0000250|UniProtKB:P56711, ECO:0000269|PubMed:26861393}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus princeps (Prince cone)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Micromolar concentrations of PiVIIA increase the magnitude of the macroscopic calcium current in DRG neurons from rat. An increase, even modest of the calcium current, may have a significant impact in the excitability and electrical activity of neurons, and may set up PiVIIA as a member of the pharmacological family of the gamma-conotoxins..
Gamma-conotoxin PiVIIA
cone snail
Conotoxin O2 superfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin O2 superfamily
Gamma-conotoxin PiVIIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail