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Peptide record

TPDB28760

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB28760
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CCSALCSRYHCLPCC
Physicochemical Analysis
C65H104N20O19S6
NDEQGIKMFTWV
C
1662.02
7.64
2
0
4
+1
-1.19
0.813
58.67
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
112.21
9
Residue Composition
number
1
A
1
R
0
N
0
D
6
C
0
E
0
Q
0
G
1
H
0
I
2
L
0
K
0
M
0
F
1
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C65H104N20O19S6
1662.02
7.64
+1
-1.19
0.813
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Slowly and reversibly inhibits human nicotinic acetylcholine receptors (nAChR) alpha-7/CHRNA7 (IC(50)=45.7 uM). It is unknown whether it inhibits nAChRs by a competitive or a non-competitive mechanism. {ECO:0000269|PubMed:35307452}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus archon (Magistrate cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Slowly and reversibly inhibits human nicotinic acetylcholine receptors (nAChR) alpha-7/CHRNA7 (IC(50)=45.7 uM). It is unknown whether it inhibits nAChRs by a competitive or a non-competitive mechanism..
Conotoxin ArchIIIA (F27-1)
cone snail
Conotoxin M superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:35307452}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin M superfamily
Conotoxin ArchIIIA (F27-1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:35307452}.
cone snail