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Peptide record

TPDB28719

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB28719
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CAAFGSFCGLPGLVDCCSGRCFIVCLL
Physicochemical Analysis
C120H188N30O32S6
NEQHKMTWY
C
2755.35
5.71
1
1
12
-0
-4.79
1.567
101.11
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
13.61
8
Residue Composition
number
2
A
1
R
0
N
1
D
6
C
0
E
0
Q
4
G
0
H
1
I
4
L
0
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 4 K: 0 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
27
C120H188N30O32S6
2755.35
5.71
-0
-4.79
1.567
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. This toxin inhibits tetrodotoxin(TTX)-sensitive sodium channels. A test on mouse Nav1.6/SCN8A confirms this sensitivity. {ECO:0000269|PubMed:25848010}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tessulatus (Tessellate cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. This toxin inhibits tetrodotoxin(TTX)-sensitive sodium channels.
Delta-conotoxin TsVIA
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25848010}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin TsVIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25848010}.
cone snail