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Peptide record

TPDB28714

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB28714
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CASQGQKCKTKSDCCNGMWCAGTRGHTCYKPK
Physicochemical Analysis
C140H226N46O44S7
EILFV
C
3482.04
8.88
7
1
5
+5
5.90
-0.931
6.25
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7365
211.51
15
Residue Composition
number
2
A
1
R
1
N
1
D
6
C
0
E
2
Q
4
G
1
H
0
I
0
L
5
K
1
M
0
F
1
P
2
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 2 G: 4 H: 1 I: 0 L: 0 K: 5 M: 1 F: 0 P: 1 S: 2 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
32
C140H226N46O44S7
3482.04
8.88
+5
5.90
-0.931
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly inhibits acid-sensing ion channels (ASIC) in rat dorsal root ganglia neurons (IC(50)=100 nM). Reversibly inhibits voltage-gated potassium channels (Kv) in rat DRG neurons (IC(50)=3.5 uM). {ECO:0000269|PubMed:23764262}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phymanthus crucifer (Red beaded anemone)
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Reversibly inhibits acid-sensing ion channels (ASIC) in rat dorsal root ganglia neurons (IC(50)=100 nM). Reversibly inhibits voltage-gated potassium channels (Kv) in rat DRG neurons (IC(50)=3.5 uM)..
Pi-phymatoxin-Pcf1a (Pi-PMTX-Pcf1a) (Pi-PMTX-Pcr1a) (Toxin PhcrTx1)
sea anemone
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
Additional Detail Fields 5 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Evidence at protein level
Pi-phymatoxin-Pcf1a (Pi-PMTX-Pcf1a) (Pi-PMTX-Pcr1a) (Toxin PhcrTx1)
sea anemone