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Peptide record

TPDB28704

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB28704
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQSTITGLFKKC
Physicochemical Analysis
C205H319N59O59S9
HV
C
4842.69
8.51
7
2
11
+5
3.64
-0.595
32.62
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
14480
299.01
20
Residue Composition
number
2
A
1
R
3
N
1
D
8
C
1
E
3
Q
3
G
0
H
2
I
1
L
6
K
1
M
1
F
1
P
2
S
2
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 1 C: 8 E: 1 Q: 3 G: 3 H: 0 I: 2 L: 1 K: 6 M: 1 F: 1 P: 1 S: 2 T: 2 W: 2 Y: 2 V: 0
Chemical Descriptors
42
C205H319N59O59S9
4842.69
8.51
+5
3.64
-0.595
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits tetrodotoxin-sensitive sodium channels by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels (Nav). {ECO:0000269|PubMed:15066415}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Illawarra wisharti (Illawarra funnel-web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits tetrodotoxin-sensitive sodium channels by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers.
Delta-hexatoxin-Iw1a (Delta-HXTX-Iw1a) (Delta-atracotoxin-Hs20.1a) (Delta-ACTX-Hs20.1a)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15066415}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Iw1a (Delta-HXTX-Iw1a) (Delta-atracotoxin-Hs20.1a) (Delta-ACTX-Hs20.1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15066415}.
spider