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Peptide record

TPDB28703

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB28703
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
CAKKREWCAKTEDCCCPMKCIYAWYNEQSSCQTTFSGMFKKC
Physicochemical Analysis
C210H320N56O62S10
HLV
C
4941.79
8.09
7
4
12
+3
5.85
-0.571
16.43
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
14480
293.01
19
Residue Composition
number
3
A
1
R
1
N
1
D
8
C
3
E
2
Q
1
G
0
H
1
I
0
L
6
K
2
M
2
F
1
P
3
S
3
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 1 C: 8 E: 3 Q: 2 G: 1 H: 0 I: 1 L: 0 K: 6 M: 2 F: 2 P: 1 S: 3 T: 3 W: 2 Y: 2 V: 0
Chemical Descriptors
42
C210H320N56O62S10
4941.79
8.09
+3
5.85
-0.571
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that slows the inactivation of vertebrate tetrodotoxin-sensitive voltage-gated sodium channels (Nav) and most likely insect sodium channels presumably by binding to site 3 of the channel. Effects are an increase in resting tension, a muscle fasciculation and a decrease in indirect twitch tension. It fails to affect tetrodotoxin-resistant sodium currents. In vivo, is lethal to both vertebrates and insects. {ECO:0000269|PubMed:14596942}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Missulena bradleyi (Eastern mouse spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin that slows the inactivation of vertebrate tetrodotoxin-sensitive voltage-gated sodium channels (Nav) and most likely insect sodium channels presumably by binding to site 3 of the channel. Effects are an increase in resting tension, a muscle fasciculation and a decrease in indirect twitch tension.
Delta-actinopoditoxin-Mb1a (Delta-AOTX-Mb1a) (Delta-missulenatoxin-Mb1a) (Delta-MSTX-Mb1a)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14596942}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-actinopoditoxin-Mb1a (Delta-AOTX-Mb1a) (Delta-missulenatoxin-Mb1a) (Delta-MSTX-Mb1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14596942}.
spider