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Peptide record

TPDB28698

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB28698
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CAGIGSFCGLPGLVDCCSDRCFIVCLP
Physicochemical Analysis
C117H186N30O34S6
NEQHKMTWY
C
2749.30
3.88
1
2
10
-1
-1.56
1.233
97.41
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
13.64
8
Residue Composition
number
1
A
1
R
0
N
2
D
6
C
0
E
0
Q
4
G
0
H
2
I
3
L
0
K
0
M
2
F
2
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 2 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 3 K: 0 M: 0 F: 2 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
27
C117H186N30O34S6
2749.30
3.88
-1
-1.56
1.233
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This toxin activates voltage-gated sodium channels (Nav1.3/SCN3A (EC(50)=3.98 nM), Nav1.4/SCN4A (EC(50)=4.99 nM), Nav1.6/SCN8A (EC(50)=1.27 nM) and Nav1.7/SCN9A (EC(50)=2.42 nM)). It shifts the voltage-dependence of activation to more hyperpolarized potentials but has only little effect on channel inactivation. In vivo, it induces nocifensive or pain-like behaviors in mice when injected intraplantarly. This is coherent with the specific defensive role deduced from its proximal position in the venom gland. {ECO:0000269|PubMed:26156767}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus suturatus (Sutured cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
This toxin activates voltage-gated sodium channels (Nav1.3/SCN3A (EC(50)=3.98 nM), Nav1.4/SCN4A (EC(50)=4.99 nM), Nav1.6/SCN8A (EC(50)=1.27 nM) and Nav1.7/SCN9A (EC(50)=2.42 nM)). It shifts the voltage-dependence of activation to more hyperpolarized potentials but has only little effect on channel inactivation.
Delta-conotoxin SuVIA (Delta-SuVIA)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct, in the proximal part (indicative of a defensive role). {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin SuVIA (Delta-SuVIA)
TISSUE SPECIFICITY: Expressed by the venom duct, in the proximal part (indicative of a defensive role). {ECO:0000305}.
cone snail