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Peptide record

TPDB28637

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB28637
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CCKYGWTCLLGCSPCGC
Physicochemical Analysis
C74H113N19O21S6
ARNDEQHIMFV
C
1797.19
7.62
1
0
4
+1
-3.61
0.718
45.88
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7365
409.81
9
Residue Composition
number
0
A
0
R
0
N
0
D
6
C
0
E
0
Q
3
G
0
H
0
I
2
L
1
K
0
M
0
F
1
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
17
C74H113N19O21S6
1797.19
7.62
+1
-3.61
0.718
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes. Induces paralysis in bivalve mollusks (Mytilus). No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga). PnIVB is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus pennaceus (Feathered cone) (Conus episcopus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes.
Mu-conotoxin PnIVA
cone snail
Conotoxin M superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin PnIVA
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail