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Peptide record

TPDB28593

Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB28593
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CCGVPNAACPPCVCNKTCG
Physicochemical Analysis
C71H118N22O23S6
RDEQHILMFSWY
C
1840.21
7.63
1
0
4
+1
1.70
0.516
41.05
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
20.38
9
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
3
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C71H118N22O23S6
1840.21
7.63
+1
1.70
0.516
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) subunits) (IC(50)=66 nM) with 1500/2000-fold greater affinity than the adult (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE)) subtype (IC(50)=96000 nM). It blocks the currents completely and dissociates rapidly from the fetal muscle receptor. Has no inhibitory activity on various neuronal nAChRs. This toxin causes a reversible paralysis upon injection into gold fish. {ECO:0000269|PubMed:15659611, ECO:0000269|PubMed:16430227}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus obscurus (Obscure cone) (Conus halitropus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) subunits) (IC(50)=66 nM) with 1500/2000-fold greater affinity than the adult (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE)) subtype (IC(50)=96000 nM).
Alpha-conotoxin OIVB (Alpha-A-O4b) (Alpha-A-OIVB)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:15659611}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin OIVB (Alpha-A-O4b) (Alpha-A-OIVB)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:15659611}.
cone snail