Back to search

Peptide record

TPDB28589

Neurotoxin Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28589
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
CCGVPNAACHPCVCKNTC
Physicochemical Analysis
C70H115N23O22S6
RDEQILMFSWY
C
1823.18
7.64
2
0
4
+1
2.20
0.478
43.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
20.57
9
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
0
E
0
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
18
C70H115N23O22S6
1823.18
7.64
+1
2.20
0.478
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1/beta-1/gamma/delta subunits) (IC(50)=0.51 nM) with 600-fold greater affinity than the adult subtype (IC(50)=310 nM). It blocks the elicited currents completely and it dissociates very slowly from the fetal muscle receptor. This toxin causes an apparently irreversible paralysis upon intramuscular injection into gold fish. {ECO:0000269|PubMed:16430227}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus obscurus (Obscure cone) (Conus halitropus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1/beta-1/gamma/delta subunits) (IC(50)=0.51 nM) with 600-fold greater affinity than the adult subtype (IC(50)=310 nM).
Alpha-conotoxin OIVA (Alpha-A-O4a) (Alpha-A-OIVA)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin OIVA (Alpha-A-O4a) (Alpha-A-OIVA)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail