TPDB

3D PDB MODEL

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TPDB ID TPDB28534

Activity

Neurotoxin Toxicity

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2 Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.

Sequence

AYTTEQCRALNGTCRFYACFPKNVVIGKCDWLG

FASTA

>TPDB28534|Neurotoxin;Toxicity|length=33
AYTTEQCRALNGTCRFYACFPKNVVIGKCDWLG

Formula C165H251N45O46S4

Absent Amino Acids HMS

Common Amino Acids C

Mass 3729.32

PI 8.29

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +2

Boman Index 0.42

Hydrophobicity -0.036

Aliphatic Index 62.12

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 8730

Absorbance 280nm 234.09

Polar Residues 12

number

3

A

2

R

2

N

1

D

4

C

1

E

1

Q

3

G

0

H

1

I

2

L

2

K

0

M

2

F

1

P

0

S

3

T

1

W

2

Y

2

V

Amino Acid Distribution

A: 3 R: 2 N: 2 D: 1 C: 4 E: 1 Q: 1 G: 3 H: 0 I: 1 L: 2 K: 2 M: 0 F: 2 P: 1 S: 0 T: 3 W: 1 Y: 2 V: 2

Length

33

Formula

C165H251N45O46S4

Mass

3729.32

PI

8.29

Net Charge

+2

Boman Index

0.42

Hydrophobicity

-0.036

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Lethal toxin which possesses an inhibitory effect on direct electrical stimulation of the isolated hemi-diaphragm. Neither hemorrhagic nor hemolytic activities are detected. Phospholipase A2 activity, proteolytic activity and arginine esterolytic activity are absent. {ECO:0000269|PubMed:3401225}.

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Heloderma horridum horridum (Mexican beaded lizard)

Neurotoxin Type Neurotoxin

Mechanism

Lethal toxin which possesses an inhibitory effect on direct electrical stimulation of the isolated hemi-diaphragm. Neither hemorrhagic nor hemolytic activities are detected.

Protein Name Helofensin-1 (Lethal toxin)

Venom Taxon Group other

Protein Family Beta-defensin family, Helofensin subfamily

Protein Existence Evidence at protein level

Keywords Direct protein sequencing Neurotoxin Secreted Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:3401225}.

Keywords

Direct protein sequencing Neurotoxin Secreted Toxin

Neurotoxin_Type

Neurotoxin

Protein_Existence

Evidence at protein level

Protein_Family

Beta-defensin family, Helofensin subfamily

Protein_Name

Helofensin-1 (Lethal toxin)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:3401225}.

Venom_Taxon_Group

other