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Peptide record

TPDB28517

Neurotoxin Toxicity standard
55 amino acids
Basic Information
3D PDB MODEL
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TPDB28517
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 55-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AWKCLPKDSTCGDDCDCCEGLHCHCPLRNMLPAILRCSCQSKDDHINTCPKYKKS
Physicochemical Analysis
C255H409N77O80S11
FV
C
6186.18
7.42
11
7
12
+1
14.70
-0.591
53.27
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7615
123.10
20
Residue Composition
number
2
A
2
R
2
N
6
D
10
C
1
E
1
Q
2
G
3
H
2
I
5
L
6
K
1
M
0
F
4
P
4
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 6 C: 10 E: 1 Q: 1 G: 2 H: 3 I: 2 L: 5 K: 6 M: 1 F: 0 P: 4 S: 4 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
55
C255H409N77O80S11
6186.18
7.42
+1
14.70
-0.591
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity). Is both paralytic and lethal when injected into lepidopteran larvae. Is not toxic to mice. {ECO:0000250, ECO:0000269|PubMed:18606178}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Oxyopes lineatus (Lynx spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity). Is both paralytic and lethal when injected into lepidopteran larvae.
Omega-oxotoxin-Ol1b (Omega-OXTX-Ol1b) (Oxytoxin-2) (OxyTx2)
spider
Spiderine family, Spiderine subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18606178}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Spiderine family, Spiderine subfamily
Omega-oxotoxin-Ol1b (Omega-OXTX-Ol1b) (Oxytoxin-2) (OxyTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18606178}.
spider