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Peptide record

TPDB28488

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB28488
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AVCVYRTCDKDCKRRGYRSGKCINNACKCYPYA
Physicochemical Analysis
C159H255N51O46S6
EQHLMFW
C
3809.45
9.14
8
2
10
+6
5.36
-0.709
38.48
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6335
166.30
14
Residue Composition
number
3
A
4
R
2
N
2
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
4
K
0
M
0
F
1
P
1
S
1
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 3 R: 4 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 4 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 4 V: 2
Chemical Descriptors
33
C159H255N51O46S6
3809.45
9.14
+6
5.36
-0.709
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium channel Kv1.2/KCNA2 (IC(50)=3.6 nM) and Kv1.3/KCNA3 (IC(50)=72 nM). {ECO:0000269|PubMed:26921461}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium channel Kv1.2/KCNA2 (IC(50)=3.6 nM) and Kv1.3/KCNA3 (IC(50)=72 nM)..
Potassium channel toxin alpha-KTx 10.4 (Toxin II.10.4)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Potassium channel toxin alpha-KTx 10.4 (Toxin II.10.4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
scorpion