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Peptide record

TPDB28453

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB28453
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ATCAGQDKPCKVNCDCCGERGECVCGGPCICRQGNVFIAWSKLMTCK
Physicochemical Analysis
C202H330N62O63S11
HY
C
4987.88
7.72
6
4
12
+2
8.36
-0.017
49.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6125
122.80
17
Residue Composition
number
3
A
2
R
2
N
2
D
10
C
2
E
2
Q
6
G
0
H
2
I
1
L
4
K
1
M
1
F
2
P
1
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 2 C: 10 E: 2 Q: 2 G: 6 H: 0 I: 2 L: 1 K: 4 M: 1 F: 1 P: 2 S: 1 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
47
C202H330N62O63S11
4987.88
7.72
+2
8.36
-0.017
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits the inactivation of voltage-gated sodium channels (Nav). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ancylometes sp. (South American fishing spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits the inactivation of voltage-gated sodium channels (Nav)..
Delta-ctenitoxin-Asp2e (Delta-CNTX-Asp2e) (Neurotoxin ANC45C1)
spider
Neurotoxin 03 (Tx2) family, 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 06 subfamily
Delta-ctenitoxin-Asp2e (Delta-CNTX-Asp2e) (Neurotoxin ANC45C1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider