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Peptide record

TPDB28452

Neurotoxin Toxicity standard
54 amino acids
Basic Information
3D PDB MODEL
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TPDB28452
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 54-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
ATCAGQDKPCKETCDCCGERGECVCGLSYEGKYRCICRQGTFLIAWYKLASCKK
Physicochemical Analysis
C251H400N72O77S10
NHM
C
5978.97
7.95
9
6
15
+3
10.15
-0.330
48.89
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
10595
177.20
20
Residue Composition
number
4
A
3
R
0
N
2
D
10
C
4
E
2
Q
6
G
0
H
2
I
3
L
6
K
0
M
1
F
1
P
2
S
3
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 2 C: 10 E: 4 Q: 2 G: 6 H: 0 I: 2 L: 3 K: 6 M: 0 F: 1 P: 1 S: 2 T: 3 W: 1 Y: 3 V: 1
Chemical Descriptors
54
C251H400N72O77S10
5978.97
7.95
+3
10.15
-0.330
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav). Causes immediate spastic paralysis and death in mice within 1 minute of injection at dose levels of 1.5 ug per mouse. {ECO:0000269|Ref.2}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav). Causes immediate spastic paralysis and death in mice within 1 minute of injection at dose levels of 1.5 ug per mouse..
U7-ctenitoxin-Pk1a (U7-CNTX-Pk1a) (Neurotoxin PKTx36C1)
spider
Neurotoxin 03 (Tx2) family, 04 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 04 subfamily
U7-ctenitoxin-Pk1a (U7-CNTX-Pk1a) (Neurotoxin PKTx36C1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
spider