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Peptide record

TPDB28416

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB28416
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ASCKCDDDGPDVRSATFTGTVDFWNCNEGWEKCTAVYTPVASCCRKKK
Physicochemical Analysis
C224H343N63O74S6
QHILM
C
5294.93
6.20
7
7
13
-0
10.88
-0.600
32.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12865
242.97
17
Residue Composition
number
4
A
2
R
2
N
5
D
6
C
2
E
0
Q
3
G
0
H
0
I
0
L
5
K
0
M
2
F
2
P
3
S
5
T
2
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 5 C: 6 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 5 M: 0 F: 2 P: 2 S: 3 T: 5 W: 2 Y: 1 V: 4
Chemical Descriptors
48
C224H343N63O74S6
5294.93
6.20
-0
10.88
-0.600
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:2412579). Its toxicity is weaker than that of RpIII (AC P08380) (PubMed:2412579). {ECO:0000269|PubMed:2412579}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:2412579). Its toxicity is weaker than that of RpIII (AC P08380) (PubMed:2412579)..
Delta-stichotoxin-Hmg4a (Delta-SHTX-Hmg4a) (Delta-stichotoxin-Rpa1a) (Delta-SHTX-Rpa1a) (RpII) (Toxin II)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hmg4a (Delta-SHTX-Hmg4a) (Delta-stichotoxin-Rpa1a) (Delta-SHTX-Rpa1a) (RpII) (Toxin II)
sea anemone