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Peptide record

TPDB28414

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB28414
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ASCKCDDDGPDVRSATFTGTVDFAYCNAGWEKCLAVYTPVASCCRKKK
Physicochemical Analysis
C221H343N61O71S6
QHIM
AC
5182.88
7.62
7
6
16
+1
8.31
-0.294
44.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8855
170.85
16
Residue Composition
number
6
A
2
R
1
N
5
D
6
C
1
E
0
Q
3
G
0
H
0
I
1
L
5
K
0
M
2
F
2
P
3
S
4
T
1
W
2
Y
4
V
Amino Acid Distribution
A: 6 R: 2 N: 1 D: 5 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 5 M: 0 F: 2 P: 2 S: 3 T: 4 W: 1 Y: 2 V: 4
Chemical Descriptors
48
C221H343N61O71S6
5182.88
7.62
+1
8.31
-0.294
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. {ECO:0000250|UniProtKB:P30832}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process..
Delta-stichotoxin-Hcr1e (Delta-SHTX-Hcr1e) (Neurotoxin I) (RTX-I) (Rm1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hcr1e (Delta-SHTX-Hcr1e) (Neurotoxin I) (RTX-I) (Rm1)
sea anemone