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Peptide record

TPDB28407

Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB28407
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ASGADTCCSNPACQVQHSDLC
Physicochemical Analysis
C80H128N26O33S4
REIKMFWY
C
2110.29
3.88
1
2
5
-2
4.03
-0.114
46.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
250
11.85
11
Residue Composition
number
3
A
0
R
1
N
2
D
4
C
0
E
2
Q
1
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
3
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 2 C: 4 E: 0 Q: 2 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C80H128N26O33S4
2110.29
3.88
-2
4.03
-0.114
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3.51 uM) and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=0.94 uM) nAChRs. {ECO:0000269|PubMed:33801301}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus catus (Cat cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3.51 uM) and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=0.94 uM) nAChRs..
Alpha-conotoxin CIC (C1.1) (Ca001)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26322961}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin CIC (C1.1) (Ca001)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26322961}.
cone snail