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Peptide record

TPDB28401

Neurotoxin Toxicity standard
81 amino acids
Basic Information
3D PDB MODEL
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TPDB28401
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 81-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
ARGDAEKWESLISEERACKGEGVKGCYDKPDDWCCKKTPCKCPAWSHERECRCTQPCARRCRGKRALMLDPETHRLLFSED
Physicochemical Analysis
C392H624N124O121S11
N
C
9362.69
7.73
19
15
19
+2
32.20
-1.052
39.88
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
18615
198.82
19
Residue Composition
number
6
A
9
R
0
N
6
D
10
C
9
E
1
Q
5
G
2
H
1
I
5
L
8
K
1
M
1
F
5
P
4
S
3
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 6 R: 9 N: 0 D: 6 C: 10 E: 9 Q: 1 G: 5 H: 2 I: 1 L: 5 K: 8 M: 1 F: 1 P: 5 S: 4 T: 3 W: 3 Y: 1 V: 1
Chemical Descriptors
81
C392H624N124O121S11
9362.69
7.73
+2
32.20
-1.052
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium (Cav) channels. {ECO:0000250|UniProtKB:Q6B4T5}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Loxosceles intermedia (Brown spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium (Cav) channels..
U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4)
spider
Neurotoxin 28 (Litx) family
Evidence at transcript level
Amidation Calcium channel impairing toxin Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Neurotoxin 28 (Litx) family
U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider