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Peptide record

TPDB28268

Neurotoxin Toxicity standard
58 amino acids
Basic Information
3D PDB MODEL
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TPDB28268
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 58-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
AKDGDVKGPAGCMKYKSGDCRGKTCCDQQYLWYKWRNLACRCFTVEVFKKDCWCNDIS
Physicochemical Analysis
C291H444N82O84S9
H
CK
6723.77
8.30
11
7
18
+4
8.28
-0.669
40.34
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
21470
319.32
19
Residue Composition
number
3
A
3
R
2
N
6
D
8
C
1
E
2
Q
5
G
0
H
1
I
2
L
8
K
1
M
2
F
1
P
2
S
2
T
3
W
3
Y
3
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 6 C: 8 E: 1 Q: 2 G: 5 H: 0 I: 1 L: 2 K: 8 M: 1 F: 2 P: 1 S: 2 T: 2 W: 3 Y: 3 V: 3
Chemical Descriptors
58
C291H444N82O84S9
6723.77
8.30
+4
8.28
-0.669
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts by delaying the inactivation of presynaptic voltage-sensitive sodium channels (Nav). Acts against insects and cause a progressive spastic paralysis.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Diguetia canities (Desert bush spider) (Segestria canities)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Acts by delaying the inactivation of presynaptic voltage-sensitive sodium channels (Nav). Acts against insects and cause a progressive spastic paralysis.
Mu-diguetoxin-Dc1b (Mu-DGTX-Dc1b) (Insecticidal toxin DTX11)
spider
Neurotoxin 26 (DTX) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8541888}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 26 (DTX) family
Mu-diguetoxin-Dc1b (Mu-DGTX-Dc1b) (Insecticidal toxin DTX11)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8541888}.
spider