Back to search

Peptide record

TPDB28266

Neurotoxin Toxicity modified_plain modified
61 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28266
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 61-aa modified multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AKDGDFEGPPGCLKMGELCKGGTCCTKVYKYWKWRKLECLGKNDGWFKKKFICDEPCNPXX
Physicochemical Analysis
C302H460N78O82S8
QHS
K
6751.93
8.41
12
8
16
+4
12.32
-0.741
38.36
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
19855
294.06
13
Residue Composition
number
1
A
1
R
2
N
4
D
7
C
4
E
0
Q
8
G
0
H
1
I
4
L
11
K
1
M
3
F
4
P
0
S
2
T
3
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 4 C: 7 E: 4 Q: 0 G: 8 H: 0 I: 1 L: 4 K: 11 M: 1 F: 3 P: 4 S: 0 T: 2 W: 3 Y: 2 V: 1
Chemical Descriptors
61
C302H460N78O82S8
6751.93
8.41
+4
12.32
-0.741
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts by delaying the inactivation of presynaptic voltage-sensitive sodium channels (Nav). Acts against insects and causes a progressive spastic paralysis.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Diguetia canities (Desert bush spider) (Segestria canities)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Acts by delaying the inactivation of presynaptic voltage-sensitive sodium channels (Nav). Acts against insects and causes a progressive spastic paralysis.
Mu-diguetoxin-Dc1c (Mu-DGTX-Dc1c) (Insecticidal toxin DTX12)
spider
Neurotoxin 26 (DTX) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 26 (DTX) family
Mu-diguetoxin-Dc1c (Mu-DGTX-Dc1c) (Insecticidal toxin DTX12)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider