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Peptide record

TPDB28212

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB28212
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AGGKSTCCPCAMCKYTAGCPWGQCAHHCGCSE
Physicochemical Analysis
C129H196N40O41S9
RNDILFV
C
3251.76
7.51
4
1
7
+1
2.37
-0.078
12.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7490
230.34
14
Residue Composition
number
4
A
0
R
0
N
0
D
8
C
1
E
1
Q
5
G
2
H
0
I
0
L
2
K
1
M
0
F
2
P
2
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 8 E: 1 Q: 1 G: 5 H: 2 I: 0 L: 0 K: 2 M: 1 F: 0 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
32
C129H196N40O41S9
3251.76
7.51
+1
2.37
-0.078
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to sodium channels (Nav) of the axonal membrane of crayfish and prolongs the falling phase of the action potential. It also increases the maximum rates of rise of both action potential and resting potential (PubMed:6107210). Is only active on crustaceans. {ECO:0000269|PubMed:37290, ECO:0000269|PubMed:6107210}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Entacmaea quadricolor (Bubble-tip anemone) (Parasicyonis actinostoloides)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to sodium channels (Nav) of the axonal membrane of crayfish and prolongs the falling phase of the action potential. It also increases the maximum rates of rise of both action potential and resting potential (PubMed:6107210).
Delta-actitoxin-Eqd1a (Delta-AITX-Eqd1a) (Delta-actitoxin-Ers1a) (Delta-AITX-Ers1a) (Er-I) (Er I) (Neurotoxin 3 homolog) (Neurotoxin III homolog) (Parasicyonis toxin) (PATX)
sea anemone
Sea anemone short toxin (type III) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone short toxin (type III) family
Delta-actitoxin-Eqd1a (Delta-AITX-Eqd1a) (Delta-actitoxin-Ers1a) (Delta-AITX-Ers1a) (Er-I) (Er I) (Neurotoxin 3 homolog) (Neurotoxin III homolog) (Parasicyonis toxin) (PATX)
sea anemone