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Peptide record

TPDB28210

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB28210
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AGGKATCCPCFMCSYTAGCPWGQCAHHCGCD
Physicochemical Analysis
C128H186N38O39S9
RNEILV
C
3169.66
6.84
3
1
8
-0
-0.67
0.161
12.90
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7490
236.30
13
Residue Composition
number
4
A
0
R
0
N
1
D
8
C
0
E
1
Q
5
G
2
H
0
I
0
L
1
K
1
M
1
F
2
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 1 C: 8 E: 0 Q: 1 G: 5 H: 2 I: 0 L: 0 K: 1 M: 1 F: 1 P: 2 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
31
C128H186N38O39S9
3169.66
6.84
-0
-0.67
0.161
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. {ECO:0000250|UniProtKB:P09949}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dofleinia armata (Armed anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction..
Delta-actitoxin-Dar1b (Delta-AITX-Dar1b) (Da II) [Cleaved into: Delta-actitoxin-Dar1a (Delta-AITX-Dar1a) (Da I)]
sea anemone
Sea anemone short toxin (type III) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone short toxin (type III) family
Delta-actitoxin-Dar1b (Delta-AITX-Dar1b) (Da II) [Cleaved into: Delta-actitoxin-Dar1a (Delta-AITX-Dar1a) (Da I)]
sea anemone