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Peptide record

TPDB28197

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB28197
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AFCNLRRCELSCRSLGLLGKCIGEECKCVPH
Physicochemical Analysis
C143H241N45O41S6
DQMTWY
C
3439.12
8.02
6
3
9
+2
6.81
0.142
88.06
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
375
10.90
9
Residue Composition
number
1
A
3
R
1
N
0
D
6
C
3
E
0
Q
3
G
1
H
1
I
5
L
2
K
0
M
1
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 6 E: 3 Q: 0 G: 3 H: 1 I: 1 L: 5 K: 2 M: 0 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C143H241N45O41S6
3439.12
8.02
+2
6.81
0.142
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks small conductance calcium-activated potassium channels. {ECO:0000269|PubMed:12239213}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks small conductance calcium-activated potassium channels..
Potassium channel toxin alpha-KTx 5.5 (Tamapin-2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Evidence at protein level
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Potassium channel toxin alpha-KTx 5.5 (Tamapin-2)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion