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Peptide record

TPDB28142

Neurotoxin Toxicity standard
74 amino acids
Basic Information
3D PDB MODEL
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TPDB28142
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 74-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
AECLMIGDTSCVPRLGRRCCYGAWCYCDQQLSCRRVGRKRECGWVEVNCKCGWSWSQRIDDWRADYSCKCPEDQ
Physicochemical Analysis
C363H558N114O109S13
HF
C
8679.90
7.63
12
10
21
+1
12.50
-0.661
46.08
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
32720
376.96
26
Residue Composition
number
3
A
9
R
1
N
6
D
12
C
4
E
4
Q
6
G
0
H
2
I
3
L
3
K
1
M
0
F
2
P
5
S
1
T
5
W
3
Y
4
V
Amino Acid Distribution
A: 3 R: 9 N: 1 D: 6 C: 12 E: 4 Q: 4 G: 6 H: 0 I: 2 L: 3 K: 3 M: 1 F: 0 P: 2 S: 5 T: 1 W: 5 Y: 3 V: 4
Chemical Descriptors
74
C363H558N114O109S13
8679.90
7.63
+1
12.50
-0.661
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potently blocks vertebrate calcium channels Cav1 and Cav2. Is the most active on Cav2.2/CACNA1B (from HEK) (IC(50)=2.3 nM), followed by Cav2.1/CACNA1A (IC(50)=4.3 nM), Cav2.2/CACNA1B (from oocyte) (IC(50)=14.4 nM), Cav1.2/CACNA1C (IC(50)=26.8 nM), and Cav2.3/CACNA1E (IC(50)=96.4 nM). {ECO:0000269|PubMed:9687583}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Kukulcania hibernalis (Southern house spider) (Filistata hibernalis)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potently blocks vertebrate calcium channels Cav1 and Cav2. Is the most active on Cav2.2/CACNA1B (from HEK) (IC(50)=2.3 nM), followed by Cav2.1/CACNA1A (IC(50)=4.3 nM), Cav2.2/CACNA1B (from oocyte) (IC(50)=14.4 nM), Cav1.2/CACNA1C (IC(50)=26.8 nM), and Cav2.3/CACNA1E (IC(50)=96.4 nM)..
Omega-filistatoxin-Kh1a (Omega-FLTX-Kh1a) (Toxin DW13.3)
spider
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-filistatoxin-Kh1a (Omega-FLTX-Kh1a) (Toxin DW13.3)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider