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Peptide record

TPDB28128

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB28128
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ADCVGDGQRCADWAGPYCCSGYYCSCRSMPYCRCRSDS
Physicochemical Analysis
C168H248N52O57S9
NEHILKFT
C
4196.67
5.94
4
4
10
-0
2.13
-0.497
15.53
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11960
284.99
18
Residue Composition
number
3
A
4
R
0
N
4
D
8
C
0
E
1
Q
4
G
0
H
0
I
0
L
0
K
1
M
0
F
2
P
5
S
0
T
1
W
4
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 4 C: 8 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 2 S: 5 T: 0 W: 1 Y: 4 V: 1
Chemical Descriptors
38
C168H248N52O57S9
4196.67
5.94
-0
2.13
-0.497
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces irreversible neuromuscular blockade in house crickets (A.domesticus). Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2298738}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hololena curta (Funnel-web spider) (Agelena curta)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces irreversible neuromuscular blockade in house crickets (A.domesticus). Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Hc1b (Mu-AGTX-Hc1b) (Curtatoxin-2) (CT-II)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2298738}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2914898}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Aa1c (Mu-AGTX-Aa1c) (Mu-agatoxin III) (Mu-agatoxin-3)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin Presynaptic neurotoxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin Presynaptic neurotoxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Mu-agatoxin-Hc1b (Mu-AGTX-Hc1b) (Curtatoxin-2) (CT-II) Mu-agatoxin-Aa1c (Mu-AGTX-Aa1c) (Mu-agatoxin III) (Mu-agatoxin-3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2298738}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
spider