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Peptide record

TPDB28122

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB28122
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ADVPGNYPLNSYGASYYCTI
Physicochemical Analysis
C98H138N22O32S1
REQHKMFW
Y
2168.36
3.10
0
1
9
-1
-1.75
-0.170
63.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5960
274.86
10
Residue Composition
number
2
A
0
R
2
N
1
D
1
C
0
E
0
Q
2
G
0
H
1
I
1
L
0
K
0
M
0
F
2
P
2
S
1
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 4 V: 1
Chemical Descriptors
20
C98H138N22O32S1
2168.36
3.10
-1
-1.75
-0.170
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and affects the channel activation process. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus crassicauda (Arabian fat-tailed scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and affects the channel activation process..
Toxin b subunit beta
scorpion
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Toxin b subunit beta
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion