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Peptide record

TPDB28119

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB28119
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ADVPGNYPLDSYGNCYPCTILGDNQYCI
Physicochemical Analysis
C134H194N32O45S3
REHKMFW
Y
3069.38
2.82
0
3
10
-3
0.86
-0.254
69.64
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6085
198.25
13
Residue Composition
number
1
A
0
R
3
N
3
D
3
C
0
E
1
Q
3
G
0
H
2
I
2
L
0
K
0
M
0
F
3
P
1
S
1
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 3 D: 3 C: 3 E: 0 Q: 1 G: 3 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 3 S: 1 T: 1 W: 0 Y: 4 V: 1
Chemical Descriptors
28
C134H194N32O45S3
3069.38
2.82
-3
0.86
-0.254
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and affects the channel activation process. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus crassicauda (Arabian fat-tailed scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and affects the channel activation process..
Toxin a (Subcomponent a)
scorpion
Long (3 C-C) scorpion toxin superfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16762386}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (3 C-C) scorpion toxin superfamily
Toxin a (Subcomponent a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16762386}.
scorpion