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Peptide record

TPDB28111

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB28111
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ADVPGNYPLDKNGNRYY
Physicochemical Analysis
C87H126N24O28
CEQHIMFSTW
NY
1956.10
6.74
2
2
6
-0
2.96
-1.412
45.88
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
4470
228.52
6
Residue Composition
number
1
A
1
R
3
N
2
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 2 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
17
C87H126N24O28
1956.10
6.74
-0
2.96
-1.412
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels and affects the channel activation process (By similarity). Has high toxic effect on mice but no effect on B.fusca and C.partellus larvae. {ECO:0000250, ECO:0000269|PubMed:17618664}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Parabuthus liosoma (African black tail scorpion) (Parabuthus leiosoma)
Neurotoxin Ion channel impairing toxin
Binds to sodium channels and affects the channel activation process (By similarity). Has high toxic effect on mice but no effect on B.fusca and C.partellus larvae..
Mammal toxin PlMT
scorpion
Long (3 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Long (3 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Mammal toxin PlMT
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion