Back to search

Peptide record

TPDB28095

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28095
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACLGFGEKCNPSNDKCCKSSSLVCSQKHKWCKYGW
Physicochemical Analysis
C168H258N48O49S6
RIMT
CK
3926.55
8.58
7
2
8
+4
4.27
-0.646
33.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12865
327.64
15
Residue Composition
number
1
A
0
R
2
N
1
D
6
C
1
E
1
Q
3
G
1
H
0
I
2
L
6
K
0
M
1
F
1
P
5
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 0 L: 2 K: 6 M: 0 F: 1 P: 1 S: 5 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
35
C168H258N48O49S6
3926.55
8.58
+4
4.27
-0.646
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=1 uM) and rat (IC(50)=1 uM). {ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus lividus (Cobalt blue tarantula) (Haplopelma lividum)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=1 uM) and rat (IC(50)=1 uM)..
Beta-theraphotoxin-Hlv1a (Beta-TRTX-Hlv1a) (Beta-theraphotoxin-Hl1a) (Beta-TRTX-Hl1a) (Haplotoxin-1)
spider
Neurotoxin 10 (Hwtx-1) family, 10 (haplotoxin-1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 10 (haplotoxin-1) subfamily
Beta-theraphotoxin-Hlv1a (Beta-TRTX-Hlv1a) (Beta-theraphotoxin-Hl1a) (Beta-TRTX-Hl1a) (Haplotoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider