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Peptide record

TPDB28086

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB28086
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT
Physicochemical Analysis
C192H292N60O70S10
EQILMFV
C
4881.39
5.38
7
7
8
-1
9.09
-0.836
9.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
10595
217.05
21
Residue Composition
number
4
A
3
R
1
N
7
D
10
C
0
E
0
Q
3
G
1
H
0
I
0
L
3
K
0
M
0
F
1
P
1
S
6
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 7 C: 10 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 1 S: 1 T: 6 W: 1 Y: 3 V: 0
Chemical Descriptors
44
C192H292N60O70S10
4881.39
5.38
-1
9.09
-0.836
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that inhibits presynaptic voltage-gated calcium channel (Cav) in Drosophila nerve terminals, most likely through specific block of the Cav2 channel (known as Dmca1A). {ECO:0000269|PubMed:2826721, ECO:0000269|PubMed:8413602}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Plectreurys tristis (Spider) (Plectreurys bispinosus)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Toxin that inhibits presynaptic voltage-gated calcium channel (Cav) in Drosophila nerve terminals, most likely through specific block of the Cav2 channel (known as Dmca1A)..
Omega-plectoxin-Pt1a (Omega-PLTX-Pt1a) (PLTX-II) (Toxin PLTX-2)
spider
Neurotoxin 02 (plectoxin) family, 02 (plectoxin) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Lipoprotein Neurotoxin Palmitate Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Lipoprotein Neurotoxin Palmitate Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 02 (plectoxin) subfamily
Omega-plectoxin-Pt1a (Omega-PLTX-Pt1a) (PLTX-II) (Toxin PLTX-2)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider