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Peptide record

TPDB28084

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB28084
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ADCLNEGDWCADWSGPSCCGEMWCSCPGFGKCRCKK
Physicochemical Analysis
C162H238N46O51S9
QHITYV
C
3934.49
4.65
4
5
8
-1
3.54
-0.428
16.39
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
17000
432.08
12
Residue Composition
number
2
A
1
R
1
N
3
D
8
C
2
E
0
Q
5
G
0
H
0
I
1
L
3
K
1
M
1
F
2
P
3
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 3 C: 8 E: 2 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 3 M: 1 F: 1 P: 2 S: 3 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
36
C162H238N46O51S9
3934.49
4.65
-1
3.54
-0.428
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity). Has a potent activity against S.litura larvae. {ECO:0000250, ECO:0000269|PubMed:10971590}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity).
Delta-amaurobitoxin-Pl1c (Delta-AMATX-Pl1c) (Delta-palutoxin IT3) (Delta-paluIT3)
spider
Neurotoxin 07 (Beta/delta-agtx) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family
Delta-amaurobitoxin-Pl1c (Delta-AMATX-Pl1c) (Delta-palutoxin IT3) (Delta-paluIT3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
spider